A successful candidate will build and lead a team to develop, implement, benchmark, and roll out robust and reproducible NGS-based methods and assays across the company for programs in R&D, Technology Sciences, CMC and manufacturing. This candidate should be passionate about adapting existing methods and developing cutting edge methods to solve exciting and challenging problems in cell and gene therapy and contribute to Sana’s pipeline. This person should be a team player, fantastic at cross-functional communication, and willing to be in the lab performing experiments alongside their team members on a daily basis.

The ideal candidate should have a deep technical background in genomics including NGS experimental design, single cell sequencing techniques, DNA/RNA extraction, bulk sequencing, design and benchmarking of target capture panels and amplicons, and experience with Illumina sequencers. PacBio and diagnostics development (RUO or IVD) experience is a plus. This candidate should be able to partner effectively with the Bioinformatics/Computational Biology teams to build analysis pipelines and user-friendly interfaces that will be used within the Analytical Genomics group and/or company wide. The ability to work in a highly collaborative environment and an agile team first mind-set will be critical to success.

Responsibilities

  • Collaborate with the Bioinformatics/Computational Biology teams to analyze data for methods development and automate analysis workflows for the Genomics group and/or company wide
  • Supervise the build-out and maintenance of the Analytical Genomics lab equipment
  • Partner with the automation team to implement lab automation
  • Provide strategic leadership and technical expertise in genomics
  • Document protocols in a traceable way that can be rolled-out across the company. This includes providing training to cross functional teams

Requirements

  • PhD in biochemistry, molecular biology, biomedical engineering, or related field with 7+ years of relevant industry experience with a proven track record of developing new NGS protocols that are robust, reproducible, and well documented
  • Minimum of 5 years of hands-on experience with generating Illumina and/or PacBio libraries and implementing standard best practices for QC of RNA, DNA, and NGS libraries including interpretation of QC reports
  • Broad experience with single cell library prep protocols required (e.g. 10x, SMART-Seq, Drop-Seq)
  • Prior experience with design, implementation, and analysis of barcodes and UMIs, target capture panels, and long-range PCR-based protocols with appropriate controls
  • Demonstrated experience managing and leading teams composed of scientists with varying levels of industry experience
  • Familiarity with various cell isolation (e.g. flow cytometry) and tissue dissociation techniques
  • Demonstrated success in working cross functionally especially with Bioinformatics teams, troubleshooting technical issues with library preparations, and implementation of state-of-the art methods
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